


All Bosses
HP values, attack patterns, turn rotations, and strategies for every boss in Slay the Spire 2.
Act 1 — Overgrowth
2 bossesAct 1 — Underdocks
3 bosses
Lagavulin Matriarch
Soul Siphon (permanent -2 Str/-2 Dex each cycle). The longer the fight, the weaker you get.
Soul Fysh
Turn 4-5: Fade makes damage useless, then Scream + Vulnerable 3 sets up deadly incoming damage next cycle.
Waterfall Giant
Explosion on death (30-50+ dmg based on accumulated Steam). Pressure Gun escalates +5 per use.
Act 2 — Hive
3 bosses
Kaiser Crab
Laser (31-35 dmg!), Bug Sting (Weak + Frail). When one claw dies: Crab Rage — survivor gains 5 Strength + 99 Block.
Knowledge Demon
Ponder (heals 30 HP + gains Strength every cycle). Knowledge Overwhelming (24-27 multi-hit dmg).
The Insatiable
Sandpit: if counter reaches 0, you die instantly. Lunging Bite (28-31 dmg) every cycle.
Act 3 — Glory
3 bosses
Queen
You're Mine (99 Frail/Weak/Vulnerable — essentially permanent). Off with Your Head + Vulnerable = massive damage.
Test Subject
Big Pounce (45 dmg!), Multi-Claw (gains hits each use), Burning Growl (Burns + Strength).
Doormaker
Get Back In (40-45 dmg + 5 permanent Strength each cycle). Beam (31-34 dmg). Both escalate every cycle.