StS2 / Guides / Bosses / Queen
Queen
Boss Guide Act 3 — Glory

Queen

You're Mine (99 Frail/Weak/Vulnerable — essentially permanent). Off with Your Head + Vulnerable = massive damage.

HP 400
A8+ 419
Queen 400/419 + Amalgam 199/211

Mechanics

Chains of BindingTriple DebuffMinion

Danger Turns

You're Mine (99 Frail/Weak/Vulnerable — essentially permanent). Off with Your Head + Vulnerable = massive damage.

Attack Patterns

01 Queen — Opening Moves
T1
Puppet Strings

Applies Chains of Binding 3 (first 3 cards drawn each turn become Bound).

T2
You're Mine

Applies 99 Frail, 99 Weak, 99 Vulnerable to you.

02 Queen — While Amalgam Alive (repeats)
T3+
Burn Bright for Me

Gives 1 Strength to Amalgam, gains 20 Block.

03 Queen — After Amalgam Dies (3-move cycle)
T1
Off with Your Head

3×5 dmg (4×5 A9+).

T2
Execution

15 dmg (18 A9+).

T3
Enrage

Gains 2 Strength.

04 Torch Head Amalgam (repeating cycle)
T1-2
Tackle

18 dmg (19 A9+).

T3
Beam

8×3 dmg.

T4-5
Weak Tackle

14 dmg (15 A9+).

Strategy

1

Artifact is CRITICAL — it blocks You're Mine's 99 Frail/Weak/Vulnerable. Without it, your damage and block collapse.

2

Kill the Amalgam before turn 10 — Queen buffs it with +1 Strength every turn.

3

Amalgam is a Minion — it dies when the Queen dies, but killing Queen directly through 400 HP is slow.

4

Chains of Binding locks your first 3 drawn cards. Only 1 Bound card can be played per turn.

5

After Amalgam dies, Queen attacks directly with Off with Your Head (multi-hit) and Enrage.

6

AoE damage is efficient — it hits both Queen and Amalgam.

7

If you don't have Artifact, focus on Block and Poison/Doom that ignore the Weak debuff.

Best Counters

Artifact (blocks You're Mine)AoE damage for both targetsKill Amalgam fastPoison/Doom ignores Weak debuff
GGEZ.GG · Slay the Spire 2 · Early Access · March 2026
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